What are the advantages of PEG-modified peptides?

Polyethylene glycol modification is to add high molecular polymer (ethylene glycol) to the target molecule through covalent bonding. Polyethylene glycol modification deceives the host cell's immune system by camouflaging the polypeptide, enhances the therapeutic effect of the polypeptide, and increases the solubility and bioavailability of hydrophobic drugs. It may also prolong the circulation of peptides by reducing renal clearance.