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Peptide linkers for ADC

Peptide linkers for ADC

 

 

Antibody-drug conjugates (ADCs) are a type of targeted cancer therapy that combines the specificity of monoclonal antibodies with the cytotoxic effects of drugs. Peptide linkers play a crucial role in ADC design, as they connect the antibody and the cytotoxic payload, facilitating controlled release of the drug within the target cells. The choice of linker can impact stability, drug release kinetics, and overall efficacy of the ADC. The choice of a specific linker depends on factors such as the pharmacokinetics of the ADC, the desired release mechanism, and the characteristics of the drug payload. It's crucial to balance stability in circulation with efficient drug release at the target site to maximize the therapeutic effect of the ADC. Additionally, advancements in linker technology continue to contribute to the development of novel and improved ADCs for cancer therapy.

 

 

The advantage Of Peptide Linker

 

1. Biological Compatibility

Peptide linkers are composed of natural amino acids, which are biocompatible and less likely to induce an immune response. This can contribute to the overall safety profile of the ADC.

2. Specificity and Selectivity

Peptide linkers can be designed to incorporate specific cleavage sites for proteases that are overexpressed in the target cells. This allows for selective drug release within the tumor microenvironment, enhancing the therapeutic window.

3. Stability in Circulation

Peptide linkers can be engineered for stability in the bloodstream, minimizing premature drug release during circulation. This stability is crucial for maintaining the integrity of the ADC and preventing off-target effects.

4. Tunable Pharmacokinetics

The properties of peptide linkers, such as their size and hydrophilicity, can be fine-tuned to influence the pharmacokinetics of the ADC. This tunability allows for optimization of drug delivery and distribution in vivo.

5. Ease of Synthesis

Peptide synthesis techniques are well-established, making it relatively straightforward to design and produce peptide linkers. This ease of synthesis contributes to the scalability and cost-effectiveness of ADC manufacturing.

6. pH Sensitivity

Some peptide linkers can be designed to be pH-sensitive, allowing for drug release in the acidic environment of endosomes or lysosomes within target cells. This pH responsiveness enhances the specificity of drug delivery to cancer cells.

7. Multifunctionality

Peptide linkers can be engineered to have multiple functions, such as facilitating site-specific conjugation, improving solubility, or enhancing overall stability. This versatility contributes to the design of ADCs with optimized properties.

8. Well-Characterized Cleavage Mechanisms:

Proteolytic cleavage of peptide linkers by cellular proteases is a well-characterized biological process. This predictability allows for a better understanding of the drug release mechanism and facilitates rational design of ADCs.

 

Peptide linkers Table:

 

Product Name Structure M.W. Purity
Fmoc-val-cit-PAB-OH 601.7 96%
Boc-Val-Cit-PAB 644.7 98%
MC -Val-Cit 453.5 98%
MC-Val-Cit-PAB-Gly 673.7 95%
Alkyne-Val-Cit-PAB-OH 473.6 98%
SPDP-Val-Cit-PAB-OH 576.7 98%
Fmoc-PEG2-Val-Cit-PAB-OH 760.9 95%
NH2-PEG3-Val-Cit-PAB-OH 82.7 95%
Mal-PEG2-Val-Cit-PAB-OH 618.7 95%
Mal-Amide-PEG4-Val-Cit-PAB-OH 777.9 95%
Azido-PEG3-Val-Cit-PAB-OH 608.7 96%
Azido-PEG4-Val-Ala-PAB 566.7 95%
MC-Val-Ala-OH 381.4 95%
Mal-PEG4-Val-Ala-PAB 620.7 95%
Boc-PEG4-Val-Ala-PAB 640.8 95%
Fmoc-PEG4-Val-Ala-PAB 762.9 95%
Mal-amido-PEG8-val-gly-PAB-OH 854.0 95%/td>
Fmoc-Gly-Gly-Phe-Gly-OH 558.6 95%
Gly-Gly-Phe-Gly 336.4 95%
Mal-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide 616.6 95%
Mal-PEG8-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide 927.0 95%
MC-Gly-Gly-Phe-Gly 529.6 98%
NH2-Glu-Gly-Cit-PAB-OH 466.5 95%
Fmoc-PEG4-Glu-Gly-Cit-PAB-OH 935.43 95%
NH2-Sar10-COOH 728.81 98%
Fmoc-NH2-Sar10-COOH 951.05 98%

 

 

Products
Peptides And Proteins
Application scenarios cover new hot spots and valuable research fields, such as protein purification and detection, disease-related research, immunology and biochemistry research, scientific research peptides, medicinal peptides, etc., to meet the needs of researchers at different stages. We have a complete customer service system and technical team, each peptide product purified by HPLC, more stable quality, more timely delivery.
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Custom Peptide Services

Peptide Synthesis Platform

 

 

KS-V Peptide is committed to innovative technology development and exploring new techniques for peptide synthesis. We have provided over 30,000 high-quality peptides to more than 3,000 scientists globally. Using our independently developed advanced microwave technology for peptide synthesis, KS-V Peptide can deliver peptides in as short as 3 days. Our strict QC testing service ensures that every peptide is delivered at a high level of quality.

 

Our Technical Advantages

 

 

  • Long chain peptide chemical total synthesis platform with up to 400 amino acids, and hydrophobic peptide chemical total synthesis platform with more than 130 amino acids
  • More than 300 kinds of cyclization and modification technologies, difficult peptide cyclization
  • Provide various complex peptide intermediate compounds, including non natural amino acid modified products
  • Provide comprehensive ADC/PDC/RDC linker compounds and internationally leading coupling chemistry technology
  • Overcoming compatibility issues between peptide solid-phase synthesis and DNA solid-phase synthesis, achieving efficient and one-time solid-phase synthesis of peptide and DNA chain coupling products
  • Provide coupling of peptides and liposomes to achieve targeted LNP
  • High-efficiency chemical total synthesis technology has overcome the glycopeptide synthesis problem that has plagued the scientific and industrial circles for more than ten years
  • International leading membrane protein expression and purification technology platform
  • The fastest delivery speed in the industry, as short as 3 days

 

Ordinary peptide customized systhesis

Fast and high-quality delivery, if necessary, we will keep your synthetic peptide sequence strictly confidential and sign a confidentiality agreement with you.

 

 

 

 

Difficult peptide customized systhesis