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Description: High Performance Liquid Chromatography is an analytical technique for separating compounds in a sample matrix. Separation is achieved by dissolving the sample in a suitable solvent and injecting it into a stream of solvent called the mobile phase. The mobile phase (and injected sample) is passed through a stationary phase (HPLC column). The compounds exit the column at different times based on the affinity the compounds have for the mobile phase and the

Description: Using peptide mapping, subtle changes to the primary structure of a protein or antibody can be identified that may affect the activity of the protein or the binding affinity. Peptide mapping by LC-MS/MS is one of the most powerful qualitative assays to confirm the primary sequence of proteins or antibodies. This service can be used to compare different lots of the same proteins, antibodies or biosimilars. Service of peptide mapping analysis by LC-MS/MS includes:

Peptide Impurity Profiling Service Presence of an impurity can be a real issue in drug development. It can considerably lengthen and complicate development times if not characterized in time and incur considerable extra-costs. Sometimes the entire formulation has to be reviewed. Thats why impurity profiling analysis is an important step in drug development and drug storage. An impurity is defined as an unwanted compound remaining in a drug formulation other than the active

Exendin-4 (9-39) CAS 133514-43-9 Catalog Number KS031013 This truncated Exendin-4 peptide, Exendin (9-39) amide, is a potent Glucagon-Like Peptide 1 (GLP-1) receptor antagonist. Unlike the full length Exendin-4 (a GLP-1 agonist), Exendin (9-39) antagonizes GLP-1stimulated insulin release after food intake. It is a competitive inhibitor of Exendin-3 and Exendin-4. Technical Data for Exendin-3 (9-39) amideM. Wt3369.79FormulaC149H234N40O47SSequence(Modifications: Ser-31 = C

Glucagon (human),CAS#: 16941-32-5, Molecular Weight:3482.8 A 29 amino acid sequence containing peptide hormone processed from proglucagon that keeps glucose homeostasis in vivo in both animals and humans. It is also believed to be a potential tool in the therapeutic treatment of diabetes. Technical Data for Glucagon (Human, Porcine) M. Wt 3482.78 Formula C153H225N43O49S Sequence HSQGTFTSDYSKYLDSRRAQDFVQWLMNT Storage Store at -20C Purity 95% (HPLC) CAS Number 16941-32-5

Exendin-4; Exenatide,CAS#: 141758-74-9, Catalog Number: KS031004 Exendin-4 (Exenatide), originally isolated from Heloderma suspectum venom, stimulates acinar cAMP without causing amylase release, binds with similar affinity to the glucagon-like peptide 1 receptor, and is used in the treatment of type 2 diabetes. Technical Data for Exendin-4 M. Wt 4186.61 Formula C184H282N50O60S Sequence (Modifications: Ser-39 = C-terminal amide) Storage Store at -20C Purity 95% (HPLC) CAS

-Amyloid (1-40) (human),CAS NO.: 131438-79-4, Catalog Number: KS011003 beta-Amyloid (1-40) found to exhibit both neurotrophic and neurotoxic effects that depend on neuronal age and beta-protein concentration. Technical Data for Amyloid -Peptide (1-40) (human)M. Wt4329.86FormulaC194H295N53O58SSequenceDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVStorageStore at -20CPurity95% (HPLC)CAS Number131438-79-4PubChem ID16135555InChI KeyFEWOUVRMGWFWIH-ILZZQXMPSA-NSmiles[H]N[C@@H](CC(O)=O

-Secretase Substrate I(MCA-DNP pair),Catalog Number: KS012005,Molecular Weight:1498.7 MCA-HQKLVFFA-K(DNP)-NH2 is a fluorogenic substrate for -secretase. Upon cleavage by -secretase, 7-methoxycoumarin-4-acetyl (MCA) is released and its fluorescence can be used to quantify -secretase activity. MCA displays excitation and emission maxima at 328 and 420 nm, respectively. Catalog Number orb104488 Category Peptides Conjugation Unconjugated MW 1498.7 Da Formula C73H94N16O19

GLP-2 (1-33) (human),CAS#: 223460-79-5, Catalog Number: KS032008 This is a fragment of human intestinal growth factor glucagon-like peptide 2, GLP2, containing amino acids 146 to 178. It is an intestinotrophic growth hormone that promotes many aspects of intestinal function, including enhancement of mucosal growth and promotion of nutrient absorption. GLP-2 is a hormone that can rapidly improve intestinal epithelial barrier function. Technical Data for GLP-2 (human) M. Wt

Galanin (rat),Catalog Number: KS011010,CAS NO.:114547-31-8 Galanin (1-29) (rat, mouse) is a non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats. Technical Data for Galanin (1-29) (rat, mouse) M. Wt 3164.48 Formula C141H211N43O41 Sequence (Modification: Thr-29 = C-terminal amide) Storage Store at -20C Purity 95% (HPLC) CAS Number 114547-31