Ubiquitin is a kind of small protein widely existed in eukaryotic cells, the size of 76 amino acid
residues. Ubiquitin can interconnect with each other through enzymatic reaction, and then mediate
the degradation of target protein. Its main function is to label proteins that need to be broken
down for degradation by the 26S proteasome. Some receptors on the regulatory subunit on the 26S
proteasome can recognize the polyubiquitination protein linked to K48 and K11, and the 20S core
subunit hydrolyzes the substrate under the energy of ATPase.
At KS-V, the synthesis of each peptide requires a strict quality control process. The unique
comprehensive quality control management platform requires three reverse high performance liquid
chromatography (RP-HPLC) and mass spectrometry (MS) for each peptide in the synthesis, purification
and QC process to ensure the quality of each peptide. Additional QA rechecks are required to further
ensure high quality peptide delivery.