Detailed Introduction of Histone
Histones are the proteins that neatly condense and package DNA into chromosomes. Modification of histones is an important post-translational process that plays a key role in gene expression by altering chromatin structure or by recruiting histone modifiers to influence gene expression. Different types of histone modifications affect different processes in cells, such as activation/inactivation of transcription, chromosomal packaging, DNA damage and DNA repair. As a domestic professional peptide synthesis supplier, we provide a variety of modified histone catalog products (such as the table in the lower right corner). Custom synthesis of modified histones, from μg to g, up to 99% purity, or according to your requirements.
● Small molecule modification of histones such as methylation, acetylation, and phosphorylation;
● Ubiquitin or ubiquitin-like modification of histones;
● Multi-site, multivalent or specially modified histones;
● Modified histone cross-linking probes;
● Special labeling of modified histones, including local or site-specific isotope, site-specific fluorescence and biotin labels.
As a professional peptide synthesis supplier in China, we provide a variety of modified histones catalog products. Customized synthesis of modified histones, from ug to g with 70% to 99% purity, can also be made according to your requirements. Modified histones can be applied to nucleosome assembly and the subsequent study of biochemical function and structure.
Histones are proteins that condense and package DNA neatly into chromosomes. Different types of histone modifications affect different processes in the cell such as the activation/ inactivation of transcription, chromosome packaging, DNA damage and DNA repair. The modification of histones is an important post-translational process that plays a key role in gene expression. Histone modifications impact gene expression by changing the structure of chromatin or through the recruitment of histone modifiers.
Histones pack DNA into structures called nucleosomes, to fit the DNA molecule into the nucleus. Each of these nucleosomes has two subunits, each comprising the core histone H2A protein, histone H2B protein, histone H3 protein and histone H4 peptide, and a linker histone called H1 that acts as a stabilizer.