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Proinsulin C-Peptide (55-89) (human) CAS 11097-48-6 Catalog Number KS031003

Proinsulin C-Peptide (55-89) (human) CAS 11097-48-6 Catalog Number KS031003

Product Details:
Catalog Number:
KS031003
Product Name:
Proinsulin C-Peptide (55-89) (human)
Sequence:
RREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR
CAS NO.:
11097-48-6
Price/1mg:
$288
Purity:
≥95% (HPLC)
Molecular Formula:
C153H259N49O52
Molecular Weight:
3617.1
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Diabetes Proinsulin C-Peptide

,

Human Proinsulin C-Peptide

,

Diabetes pro insulin c peptide

Product Description

Proinsulin C-Peptide (55-89) (human),CAS#: 11097-48-6, Catalog Number: KS031003

 

Proinsulin C-peptide is the sequence of C peptide as it exists within proinsulin, the precursor to insulin which consists of insulin A chain, insulin B chain and C peptide (connecting peptide). In proinsulin, C peptide provides a means to ensure correct folding and assembly of the A and B chains. It is eventually cleaved away by proteases PC2, PC1/3 and CPE, at the flanking Arg-Arg and Lys-Arg basic residues (Arg-Arg-C peptide-Lys-Arg). Although C peptide is not present in mature insulin, it is stored in secretory granules, and eventually released into the bloodstream together with insulin in nearly equimolar amounts. Whereas insulin is metabolized quickly from circulation, C-peptide exhibits a slow turnover rate (>30 minutes).

 

The measurement of the C-peptide is an important test for the β-cell function. In the red blood cells of type 2 diabetic patients, Na+,K+, ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-d and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.

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products details
Home > Products >
Proinsulin C-Peptide (55-89) (human) CAS 11097-48-6 Catalog Number KS031003

Proinsulin C-Peptide (55-89) (human) CAS 11097-48-6 Catalog Number KS031003

Product Details:
Catalog Number:
KS031003
Product Name:
Proinsulin C-Peptide (55-89) (human)
Sequence:
RREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR
CAS NO.:
11097-48-6
Price/1mg:
$288
Purity:
≥95% (HPLC)
Molecular Formula:
C153H259N49O52
Molecular Weight:
3617.1
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470414-proinsulin-c-peptide-55-89-human-cas-11097-48-6-catalog-number-ks031003.htm
High Light: 

Diabetes Proinsulin C-Peptide

,

Human Proinsulin C-Peptide

,

Diabetes pro insulin c peptide

Product Description

Proinsulin C-Peptide (55-89) (human),CAS#: 11097-48-6, Catalog Number: KS031003

 

Proinsulin C-peptide is the sequence of C peptide as it exists within proinsulin, the precursor to insulin which consists of insulin A chain, insulin B chain and C peptide (connecting peptide). In proinsulin, C peptide provides a means to ensure correct folding and assembly of the A and B chains. It is eventually cleaved away by proteases PC2, PC1/3 and CPE, at the flanking Arg-Arg and Lys-Arg basic residues (Arg-Arg-C peptide-Lys-Arg). Although C peptide is not present in mature insulin, it is stored in secretory granules, and eventually released into the bloodstream together with insulin in nearly equimolar amounts. Whereas insulin is metabolized quickly from circulation, C-peptide exhibits a slow turnover rate (>30 minutes).

 

The measurement of the C-peptide is an important test for the β-cell function. In the red blood cells of type 2 diabetic patients, Na+,K+, ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-d and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.