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Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V
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Name
  • Name

Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Product Details:
Catalog Number:
N1030-V
Product Name:
Protoxin II
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
Na+ Channel Blocker
Sequence:
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Molecular Formula:
C169 H274 N54O48S7
Molecular Weight:
4054.85 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Protoxin II 165168-50-3

,

Lyophilized Protoxin II

,

CAS 165168-50-3

Product Description

Protoxin II,CAS#:165168-50-3,Catalog Number: N1030-V,Sequence:YCQKWMWTCDSERKCCEGMVCRLWCKKKLW

 

NaV channels and T-type Ca2+ channels, ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations.

Sources

Protoxin-II is a neurotoxin that is derived from the venom of the Peruvian green velvet tarantula (Thrixopelma pruriens).

Chemistry

ProTx-II is a 30-amino acid peptide with a molecular weight of 3826.65 Da. The structure of ProTx-II is amphipathic, with mostly hydrophobic residues on one face of the toxin. The toxin is formed by an inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region.

Target

ProTx-II inhibits several human sodium channel subtypes, ranging from Nav1.1 up to Nav1.8. However, this toxin is, at least, 100-fold more potent against Nav1.7 than other human Nav channel subtypes. At a concentration of 0.3 nM, this toxin blocks Nav1.7 by 50%.

Besides sodium channels, ProTx-II also inhibits some subtypes of voltage-gated calcium channels, Cav1.2 and Cav3.2. From the fact that ProTx-II is able to inhibit several sodium and calcium channel subtypes, we can infer that the toxin-channel interaction surface is conserved between these channels.

 

 

Tags: 

Protoxin II 165168-50-3,

Lyophilized Protoxin II,

CAS 165168-50-3

Products
products details
Home > Products >
Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V
CATALOGUE PRODUCT

Proteins

Histones

Membrane Proteins

Recombinant Proteins Expression Services

Ubiquitins

Ubiquitin

Ubiquitin Probes

Custom Peptide Services

Antigenic Peptides

Peptide Conjugations

Modified Peptides

Cyclic Peptides

Impurity Profiling

Catalog Peptides

Peptide Toxins

Peptide APIs

Peptides For Scientific Research

Diabetes Peptides

Alzheimer's Peptide

Multiple Sclerosis Peptides

Antimicrobial Peptides

Gastrointestinal Peptides

Hormone Peptide

Cardiovascular Peptides

COVID-19 Peptides

Hematology Peptides

Apoptosis Peptides

Inflammation Peptides

Cancer Peptides

Kinases Phosphatases Peptides

Miscellaneous Peptides

FRET Substrates Peptides

Immunomodulation Peptides

Enzyme Inhibitor Peptides

RGD Peptides

Neuropeptide Peptides

Peptide Analysis Services

HPLC

MS,LC-MS

MALDI-TOF

H/C/2D NMR

Elemental Analysis

Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Name
  • Name
Product Details:
Catalog Number:
N1030-V
Product Name:
Protoxin II
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
Na+ Channel Blocker
Sequence:
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Molecular Formula:
C169 H274 N54O48S7
Molecular Weight:
4054.85 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470937-lyophilized-protoxin-ii-cas-165168-50-3-catalog-number-n1030-v.htm
High Light: 

Protoxin II 165168-50-3

,

Lyophilized Protoxin II

,

CAS 165168-50-3

Product Description

Protoxin II,CAS#:165168-50-3,Catalog Number: N1030-V,Sequence:YCQKWMWTCDSERKCCEGMVCRLWCKKKLW

 

NaV channels and T-type Ca2+ channels, ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations.

Sources

Protoxin-II is a neurotoxin that is derived from the venom of the Peruvian green velvet tarantula (Thrixopelma pruriens).

Chemistry

ProTx-II is a 30-amino acid peptide with a molecular weight of 3826.65 Da. The structure of ProTx-II is amphipathic, with mostly hydrophobic residues on one face of the toxin. The toxin is formed by an inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region.

Target

ProTx-II inhibits several human sodium channel subtypes, ranging from Nav1.1 up to Nav1.8. However, this toxin is, at least, 100-fold more potent against Nav1.7 than other human Nav channel subtypes. At a concentration of 0.3 nM, this toxin blocks Nav1.7 by 50%.

Besides sodium channels, ProTx-II also inhibits some subtypes of voltage-gated calcium channels, Cav1.2 and Cav3.2. From the fact that ProTx-II is able to inhibit several sodium and calcium channel subtypes, we can infer that the toxin-channel interaction surface is conserved between these channels.

 

 

Tags: 

Protoxin II 165168-50-3,

Lyophilized Protoxin II,

CAS 165168-50-3

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Asia & Pacific: 0551-65120828
sales@ks-vpeptide.com

#A2, National Health Big Data Industrial Park, Hefei, China

About Us
DRUG DISCOVERY STRUCTURAL BIOLOGY PEPTIDES AND PROTEINS HISTONES RESOURCES NEWS ABOUT US
Subscribe Newsletter
Sitemap | Privacy Policy | China Good Quality Proteins Supplier. Copyright © 2023 ks-vpeptide.com . All Rights Reserved.