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Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Product Details:
Catalog Number:
N1030-V
Product Name:
Protoxin II
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
Na+ Channel Blocker
Sequence:
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Molecular Formula:
C169 H274 N54O48S7
Molecular Weight:
4054.85 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Protoxin II 165168-50-3

,

Lyophilized Protoxin II

,

CAS 165168-50-3

Product Description

Protoxin II,CAS#:165168-50-3,Catalog Number: N1030-V,Sequence:YCQKWMWTCDSERKCCEGMVCRLWCKKKLW

 

NaV channels and T-type Ca2+ channels, ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations.

Sources

Protoxin-II is a neurotoxin that is derived from the venom of the Peruvian green velvet tarantula (Thrixopelma pruriens).

Chemistry

ProTx-II is a 30-amino acid peptide with a molecular weight of 3826.65 Da. The structure of ProTx-II is amphipathic, with mostly hydrophobic residues on one face of the toxin. The toxin is formed by an inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region.

Target

ProTx-II inhibits several human sodium channel subtypes, ranging from Nav1.1 up to Nav1.8. However, this toxin is, at least, 100-fold more potent against Nav1.7 than other human Nav channel subtypes. At a concentration of 0.3 nM, this toxin blocks Nav1.7 by 50%.

Besides sodium channels, ProTx-II also inhibits some subtypes of voltage-gated calcium channels, Cav1.2 and Cav3.2. From the fact that ProTx-II is able to inhibit several sodium and calcium channel subtypes, we can infer that the toxin-channel interaction surface is conserved between these channels.

 

 

Products
products details
Home > Products >
Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Lyophilized Protoxin II CAS 165168-50-3 Catalog Number N1030-V

Product Details:
Catalog Number:
N1030-V
Product Name:
Protoxin II
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
Na+ Channel Blocker
Sequence:
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
Molecular Formula:
C169 H274 N54O48S7
Molecular Weight:
4054.85 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470937-lyophilized-protoxin-ii-cas-165168-50-3-catalog-number-n1030-v.htm
High Light: 

Protoxin II 165168-50-3

,

Lyophilized Protoxin II

,

CAS 165168-50-3

Product Description

Protoxin II,CAS#:165168-50-3,Catalog Number: N1030-V,Sequence:YCQKWMWTCDSERKCCEGMVCRLWCKKKLW

 

NaV channels and T-type Ca2+ channels, ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations.

Sources

Protoxin-II is a neurotoxin that is derived from the venom of the Peruvian green velvet tarantula (Thrixopelma pruriens).

Chemistry

ProTx-II is a 30-amino acid peptide with a molecular weight of 3826.65 Da. The structure of ProTx-II is amphipathic, with mostly hydrophobic residues on one face of the toxin. The toxin is formed by an inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region.

Target

ProTx-II inhibits several human sodium channel subtypes, ranging from Nav1.1 up to Nav1.8. However, this toxin is, at least, 100-fold more potent against Nav1.7 than other human Nav channel subtypes. At a concentration of 0.3 nM, this toxin blocks Nav1.7 by 50%.

Besides sodium channels, ProTx-II also inhibits some subtypes of voltage-gated calcium channels, Cav1.2 and Cav3.2. From the fact that ProTx-II is able to inhibit several sodium and calcium channel subtypes, we can infer that the toxin-channel interaction surface is conserved between these channels.