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Margatoxin Peptide CAS 145808-47-5 Catalog Number K1020-V

Margatoxin Peptide CAS 145808-47-5 Catalog Number K1020-V

Product Details:
Catalog Number:
K1020-V
Product Name:
Margatoxin
Scale:
50 μg
Price:
$161
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Molecular Formula:
C178 H286 N52O50S7
Molecular Weight:
4179.03 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Margatoxin K1020-V

,

Margatoxin 145808-47-5

,

CAS 145808-47-5

Product Description

Margatoxin,CAS#:145808-47-5,Catalog Number:K1020-V,Store at -20°C or -80°C

 

Kv1.3 selective blocker

 

Margatoxin (MgTX) is a peptide that selectively inhibits Kv1.3 voltage-dependent potassium channels. It is found in the venom of Centruroides margaritatus, also known as the Central American Bark Scorpion. Margatoxin was first discovered in 1993. It was purified from scorpion venom and its amino acid sequence was determined.

 

Structure

 

Margatoxin is a peptide of 39 amino acids with a molecular weight of 4185 Dalton. The primary amino acid sequence of margatoxin is as follows:

 

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His

Or, when translated to one-letter sequence,

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH.

 

There are disulfide bridges between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36.

 

Margatoxin is classified as a "scorpion short toxin" by Pfam, showing sequence homology with other potassium channel blockers, such as charybdotoxin (44%), kaliotoxin (54%), iberiotoxin (41%) and noxiustoxin (79%), which are also derived from scorpion venom.

Products
products details
Home > Products >
Margatoxin Peptide CAS 145808-47-5 Catalog Number K1020-V

Margatoxin Peptide CAS 145808-47-5 Catalog Number K1020-V

Product Details:
Catalog Number:
K1020-V
Product Name:
Margatoxin
Scale:
50 μg
Price:
$161
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Molecular Formula:
C178 H286 N52O50S7
Molecular Weight:
4179.03 Da
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470935-margatoxin-peptide-cas-145808-47-5-catalog-number-k1020-v.htm
High Light: 

Margatoxin K1020-V

,

Margatoxin 145808-47-5

,

CAS 145808-47-5

Product Description

Margatoxin,CAS#:145808-47-5,Catalog Number:K1020-V,Store at -20°C or -80°C

 

Kv1.3 selective blocker

 

Margatoxin (MgTX) is a peptide that selectively inhibits Kv1.3 voltage-dependent potassium channels. It is found in the venom of Centruroides margaritatus, also known as the Central American Bark Scorpion. Margatoxin was first discovered in 1993. It was purified from scorpion venom and its amino acid sequence was determined.

 

Structure

 

Margatoxin is a peptide of 39 amino acids with a molecular weight of 4185 Dalton. The primary amino acid sequence of margatoxin is as follows:

 

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His

Or, when translated to one-letter sequence,

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH.

 

There are disulfide bridges between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36.

 

Margatoxin is classified as a "scorpion short toxin" by Pfam, showing sequence homology with other potassium channel blockers, such as charybdotoxin (44%), kaliotoxin (54%), iberiotoxin (41%) and noxiustoxin (79%), which are also derived from scorpion venom.