Recombinant Proteins Expression Services

Peptides For Scientific Research

H2A.ZK121Ub,Lyophilized,Catalog Number: H1404,Store at -20°C or -80°C

Product Details:

Catalog Number:

H1404

Product Name:

H2A.ZK121Ub

Scale:

50 μg

Purity:

≥95%

Price:

$885

CAS#.:

N/A

Sequence:

SGRGKQGGKA RAKAKTRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK

Molecular Formula:

N/A

Molecular Weight:

N/A

Form:

Lyophilized

Storage:

Store At -20°C Or -80°C

Product Description

H2A.ZK121Ub Catalog Number H1404 Store at -20°C or -80°C

Chemically synthesized histone H2A.Z protein corresponding to residues with monoubiquitination K121 modification. The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. H2A.Z has been shown to be subject to C-terminal ubiquitination by the PRC1 component Ring1B.

Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response, and is essential to perceive the ambient temperature. Nucleosome occupancy of H2A.Z decreases with temperature, and in vitro assays show that H2A.Z-containing nucleosomes wrap DNA more tightly than canonical H2A nucleosomes in Arabidopsis.(Cell 140: 136–147, 2010) However, some of the other studies (Nat. Genet. 41, 941–945 and Genes Dev., 21, 1519–1529) have shown that incorporation of H2A.Z in nucleosomes, when it co-occurs with H3.3, makes them weaker. Positioning of H2A.Z containing nucleosomes around transcription start sites has now been shown to affect the downstream gene expression.