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Apamin Catalog Number:K1090-V,Store at -20°C or -80°C,Lyophilized
A Blocker of Small Conductance Ca2+-Activated K+ Channels (SK Type)
Apamin is an 18 amino acid globular peptide neurotoxin found in apitoxin (bee venom).Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, in particular cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential
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Apamin Catalog Number:K1090-V,Store at -20°C or -80°C,Lyophilized
A Blocker of Small Conductance Ca2+-Activated K+ Channels (SK Type)
Apamin is an 18 amino acid globular peptide neurotoxin found in apitoxin (bee venom).Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, in particular cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential