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Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V
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Name
  • Name

Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Product Details:
Catalog Number:
K1100-V
Product Name:
Leiurotoxin I
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
Molecular Formula:
N/A
Molecular Weight:
N/A
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Leiurotoxin Scyllatoxin

,

Scyllatoxin Neurotoxin

,

Leiurotoxin neurotoxin

Product Description

Leiurotoxin I,Catalog Number: K1100-V,Store at -20°C or -80°C,Lyophilized

 

Leiurotoxin-1 (Scyllatoxin) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Leiurotoxin-1 binds and blocks SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.

Chemistry

Leiurotoxin I is a 31-residue peptide (sequence AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH-NH2), with a helix and a short antiparallel β-sheet. This toxin is stabilized by disulfide bonds: Cys8-Cys26 and Cys12-Cys28 is bound to the β-sheet, while Cys3-Cys21 is bound to an N-terminal segment preceding the helix. Leiurotoxin adopts the ά/β motif. Especially the positively charged residues (Arg6 and Arg13, which are located in the ά helix) are important for the expression of toxin biological activities and for its receptor affinity.

Target

Scyllatoxin is a blocker of small-conductance Ca2+– activated K+ channels at 10−13–10−11 M concentrations in various cell types. This toxin shows similarity in its physiological activity and binding specificity to apamin, but both toxins show no structural similarity.

Mode of action

Scyllatoxin blocks the slow after-hyperpolarization that follows an action potential in some nerve cells.

Toxicity

Scyllatoxin induces spontaneous contractions in guinea pig taenia coli muscle cells that have been relaxed with epinephrine.

Tags: 

Leiurotoxin Scyllatoxin,

Scyllatoxin Neurotoxin,

Leiurotoxin neurotoxin

Products
products details
Home > Products >
Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V
CATALOGUE PRODUCT

Proteins

Histones

Membrane Proteins

Recombinant Proteins Expression Services

Ubiquitins

Ubiquitin

Ubiquitin Probes

Custom Peptide Services

Antigenic Peptides

Peptide Conjugations

Modified Peptides

Cyclic Peptides

Impurity Profiling

Catalog Peptides

Peptide Toxins

Peptide APIs

Peptides For Scientific Research

Diabetes Peptides

Alzheimer's Peptide

Multiple Sclerosis Peptides

Antimicrobial Peptides

Gastrointestinal Peptides

Hormone Peptide

Cardiovascular Peptides

COVID-19 Peptides

Hematology Peptides

Apoptosis Peptides

Inflammation Peptides

Cancer Peptides

Kinases Phosphatases Peptides

Miscellaneous Peptides

FRET Substrates Peptides

Immunomodulation Peptides

Enzyme Inhibitor Peptides

RGD Peptides

Neuropeptide Peptides

Peptide Analysis Services

HPLC

MS,LC-MS

MALDI-TOF

H/C/2D NMR

Elemental Analysis

Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Name
  • Name
Product Details:
Catalog Number:
K1100-V
Product Name:
Leiurotoxin I
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
Molecular Formula:
N/A
Molecular Weight:
N/A
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470940-leiurotoxin-i-scyllatoxin-neurotoxin-catalog-number-k1100-v.htm
High Light: 

Leiurotoxin Scyllatoxin

,

Scyllatoxin Neurotoxin

,

Leiurotoxin neurotoxin

Product Description

Leiurotoxin I,Catalog Number: K1100-V,Store at -20°C or -80°C,Lyophilized

 

Leiurotoxin-1 (Scyllatoxin) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Leiurotoxin-1 binds and blocks SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.

Chemistry

Leiurotoxin I is a 31-residue peptide (sequence AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH-NH2), with a helix and a short antiparallel β-sheet. This toxin is stabilized by disulfide bonds: Cys8-Cys26 and Cys12-Cys28 is bound to the β-sheet, while Cys3-Cys21 is bound to an N-terminal segment preceding the helix. Leiurotoxin adopts the ά/β motif. Especially the positively charged residues (Arg6 and Arg13, which are located in the ά helix) are important for the expression of toxin biological activities and for its receptor affinity.

Target

Scyllatoxin is a blocker of small-conductance Ca2+– activated K+ channels at 10−13–10−11 M concentrations in various cell types. This toxin shows similarity in its physiological activity and binding specificity to apamin, but both toxins show no structural similarity.

Mode of action

Scyllatoxin blocks the slow after-hyperpolarization that follows an action potential in some nerve cells.

Toxicity

Scyllatoxin induces spontaneous contractions in guinea pig taenia coli muscle cells that have been relaxed with epinephrine.

Tags: 

Leiurotoxin Scyllatoxin,

Scyllatoxin Neurotoxin,

Leiurotoxin neurotoxin

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Asia & Pacific: 0551-65120828
sales@ks-vpeptide.com

#A2, National Health Big Data Industrial Park, Hefei, China

About Us
DRUG DISCOVERY STRUCTURAL BIOLOGY PEPTIDES AND PROTEINS HISTONES RESOURCES NEWS ABOUT US
Subscribe Newsletter
Sitemap | Privacy Policy | China Good Quality Proteins Supplier. Copyright © 2023 ks-vpeptide.com . All Rights Reserved.