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Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Product Details:
Catalog Number:
K1100-V
Product Name:
Leiurotoxin I
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
Molecular Formula:
N/A
Molecular Weight:
N/A
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
High Light: 

Leiurotoxin Scyllatoxin

,

Scyllatoxin Neurotoxin

,

Leiurotoxin neurotoxin

Product Description

Leiurotoxin I,Catalog Number: K1100-V,Store at -20°C or -80°C,Lyophilized

 

Leiurotoxin-1 (Scyllatoxin) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Leiurotoxin-1 binds and blocks SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.

Chemistry

Leiurotoxin I is a 31-residue peptide (sequence AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH-NH2), with a helix and a short antiparallel β-sheet. This toxin is stabilized by disulfide bonds: Cys8-Cys26 and Cys12-Cys28 is bound to the β-sheet, while Cys3-Cys21 is bound to an N-terminal segment preceding the helix. Leiurotoxin adopts the ά/β motif. Especially the positively charged residues (Arg6 and Arg13, which are located in the ά helix) are important for the expression of toxin biological activities and for its receptor affinity.

Target

Scyllatoxin is a blocker of small-conductance Ca2+– activated K+ channels at 10−13–10−11 M concentrations in various cell types. This toxin shows similarity in its physiological activity and binding specificity to apamin, but both toxins show no structural similarity.

Mode of action

Scyllatoxin blocks the slow after-hyperpolarization that follows an action potential in some nerve cells.

Toxicity

Scyllatoxin induces spontaneous contractions in guinea pig taenia coli muscle cells that have been relaxed with epinephrine.

Products
products details
Home > Products >
Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Leiurotoxin I Scyllatoxin Neurotoxin Catalog Number K1100-V

Product Details:
Catalog Number:
K1100-V
Product Name:
Leiurotoxin I
Scale:
50 μg
Price:
$139
Purity:
≥95%
Channel Type:
K+ Channel Blocker
Sequence:
AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH
Molecular Formula:
N/A
Molecular Weight:
N/A
Form:
Lyophilized
Storage:
Store At -20°C Or -80°C
Details Link:
Https://shopping.ks-vpeptide.com/sale-470940-leiurotoxin-i-scyllatoxin-neurotoxin-catalog-number-k1100-v.htm
High Light: 

Leiurotoxin Scyllatoxin

,

Scyllatoxin Neurotoxin

,

Leiurotoxin neurotoxin

Product Description

Leiurotoxin I,Catalog Number: K1100-V,Store at -20°C or -80°C,Lyophilized

 

Leiurotoxin-1 (Scyllatoxin) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Leiurotoxin-1 binds and blocks SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them.

Chemistry

Leiurotoxin I is a 31-residue peptide (sequence AFCNLRMCQLSCRSLGLLGKCIGDKCECVKH-NH2), with a helix and a short antiparallel β-sheet. This toxin is stabilized by disulfide bonds: Cys8-Cys26 and Cys12-Cys28 is bound to the β-sheet, while Cys3-Cys21 is bound to an N-terminal segment preceding the helix. Leiurotoxin adopts the ά/β motif. Especially the positively charged residues (Arg6 and Arg13, which are located in the ά helix) are important for the expression of toxin biological activities and for its receptor affinity.

Target

Scyllatoxin is a blocker of small-conductance Ca2+– activated K+ channels at 10−13–10−11 M concentrations in various cell types. This toxin shows similarity in its physiological activity and binding specificity to apamin, but both toxins show no structural similarity.

Mode of action

Scyllatoxin blocks the slow after-hyperpolarization that follows an action potential in some nerve cells.

Toxicity

Scyllatoxin induces spontaneous contractions in guinea pig taenia coli muscle cells that have been relaxed with epinephrine.