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H3-K4me1,Lyophilized,Catalog Number: H3101,Store at -20°C or -80°C
Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, monomethylation at K4.
H3K4me1 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the mono-methylation at the 4th lysine residue of the histone H3 protein and often associated with gene enhancers. H3K4me1 is enriched at active and primed enhancers. Transcriptional enhancers control the cell-identity gene expression and are important in the cell identity. Enhancers are primed by histone H3K4 mono-/di-methyltransferase MLL4 and then are activated by histone H3K27 acetyltransferase p300.
H3K4me1 fine-tunes the enhancer activity and function rather than controls. H3K4me1 is put down by KMT2C (MLL3) and KMT2D (MLL4). LSD1, and the related LSD2/KDM1B demethylate H3K4me1 and H3K4me2.Marks associated with active gene transcription like H3K4me1 and H3K9me1 have very short half-lives.H3K4me1 with MLL3/4 can also act at promoters and repress genes.
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H3-K4me1,Lyophilized,Catalog Number: H3101,Store at -20°C or -80°C
Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, monomethylation at K4.
H3K4me1 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the mono-methylation at the 4th lysine residue of the histone H3 protein and often associated with gene enhancers. H3K4me1 is enriched at active and primed enhancers. Transcriptional enhancers control the cell-identity gene expression and are important in the cell identity. Enhancers are primed by histone H3K4 mono-/di-methyltransferase MLL4 and then are activated by histone H3K27 acetyltransferase p300.
H3K4me1 fine-tunes the enhancer activity and function rather than controls. H3K4me1 is put down by KMT2C (MLL3) and KMT2D (MLL4). LSD1, and the related LSD2/KDM1B demethylate H3K4me1 and H3K4me2.Marks associated with active gene transcription like H3K4me1 and H3K9me1 have very short half-lives.H3K4me1 with MLL3/4 can also act at promoters and repress genes.