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Ubiquitin
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Name
  • Name

Ubiquitin

Product Details:
Product Description

Ubiquitin (Ub) is ubiquitous. This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS). Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off these Ub units and controlling the overall protein population of the cell. As you might imagine, this dynamic process is important, and dysregulation can lead to an array of bad things. Thus, understanding the relations between DUB or Ub ligase activity and specific diseases would be helpful in designing inhibitors or other therapeutic interventions. Accordingly, a number of Ub-based probes for activity-based protein profiling (ABPP) have been developed, typically involving an affinity tag, such as hemagglutinin (HA) or biotin, on the N-terminus and an electrophilic warhead on the C-terminus, such as propargylamide (PA), vinyl methyl ester (VME), or dehydroalanine (Dha). However, many of these probes are limited to experiments with purified recombinant proteins or cell lysates due to poor cell penetrance. Probes really need to be able to enter cells and react with enzymes intracellularly in order to gain the most useful information for drug targeting and other efforts.

 

Ubiquitin 0

 

 

  • Ubiquitin chains of different lengths and types can be applied to biochemical functions such as interation and enzyme activity as well as structural biology study of crystals, electron microscopes and Nuclear Magnetic Resonance.
  • Ubiquitin-derived cross-linking probes can be used to detect unknown interacting proteins from normal or diseased cells and new targets foe disease treatment.
  • Ubiquitin-derived fluorescent probes can used to analyze the activity and specificity of deubiquitinase and high throughput screening of deubiquitinase inhibitors.

 

Ubiquitin 1

 

 

 

Products
products details
Home > Products >
Ubiquitin
CATALOGUE PRODUCT

Proteins

Histones

Membrane Proteins

Recombinant Proteins Expression Services

Ubiquitins

Ubiquitin

Ubiquitin Probes

Custom Peptide Services

Antigenic Peptides

Peptide Conjugations

Modified Peptides

Cyclic Peptides

Impurity Profiling

Catalog Peptides

Peptide Toxins

Peptide APIs

Peptides For Scientific Research

Diabetes Peptides

Alzheimer's Peptide

Multiple Sclerosis Peptides

Antimicrobial Peptides

Gastrointestinal Peptides

Hormone Peptide

Cardiovascular Peptides

COVID-19 Peptides

Hematology Peptides

Apoptosis Peptides

Inflammation Peptides

Cancer Peptides

Kinases Phosphatases Peptides

Miscellaneous Peptides

FRET Substrates Peptides

Immunomodulation Peptides

Enzyme Inhibitor Peptides

RGD Peptides

Neuropeptide Peptides

Peptide Analysis Services

HPLC

MS,LC-MS

MALDI-TOF

H/C/2D NMR

Elemental Analysis

Ubiquitin

Name
  • Name
Product Details:
Product Description

Ubiquitin (Ub) is ubiquitous. This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS). Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off these Ub units and controlling the overall protein population of the cell. As you might imagine, this dynamic process is important, and dysregulation can lead to an array of bad things. Thus, understanding the relations between DUB or Ub ligase activity and specific diseases would be helpful in designing inhibitors or other therapeutic interventions. Accordingly, a number of Ub-based probes for activity-based protein profiling (ABPP) have been developed, typically involving an affinity tag, such as hemagglutinin (HA) or biotin, on the N-terminus and an electrophilic warhead on the C-terminus, such as propargylamide (PA), vinyl methyl ester (VME), or dehydroalanine (Dha). However, many of these probes are limited to experiments with purified recombinant proteins or cell lysates due to poor cell penetrance. Probes really need to be able to enter cells and react with enzymes intracellularly in order to gain the most useful information for drug targeting and other efforts.

 

Ubiquitin 0

 

 

  • Ubiquitin chains of different lengths and types can be applied to biochemical functions such as interation and enzyme activity as well as structural biology study of crystals, electron microscopes and Nuclear Magnetic Resonance.
  • Ubiquitin-derived cross-linking probes can be used to detect unknown interacting proteins from normal or diseased cells and new targets foe disease treatment.
  • Ubiquitin-derived fluorescent probes can used to analyze the activity and specificity of deubiquitinase and high throughput screening of deubiquitinase inhibitors.

 

Ubiquitin 1

 

 

 

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Contact Us

Asia & Pacific: 0551-65120828
sales@ks-vpeptide.com

#A2, National Health Big Data Industrial Park, Hefei, China

About Us
DRUG DISCOVERY STRUCTURAL BIOLOGY PEPTIDES AND PROTEINS HISTONES RESOURCES NEWS ABOUT US
Subscribe Newsletter
Sitemap | Privacy Policy | China Good Quality Proteins Supplier. Copyright © 2023 ks-vpeptide.com . All Rights Reserved.